Officers said they attended the home in Widnes, Cheshire dozens of times following reports of groups "blighting the community with bad behaviour".
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Regular visitors were given fixed penalty notices after "making neighbours lives a misery", Cheshire Police said.
On Friday a closure order was finally granted, making it a crime for anyone other than the tenant to be at the property for up to three months.
Police are planning on carrying out regular checks of the house over the next three months and anyone who founds to have broken the order will be liable to arrest and face up to six months in prison, an unlimited fine or both.
It comes as police could increase on-the-spot fines for coronavirus lockdown breakers after Home Secretary Priti Patel sounded out top officers about the proposals.
The home secretary begged fed-up Brits to respect the lockdown yesterday as the coronavirus death toll topped 20,000.
Superintendent Julie Westgate said: "In this case, those who have been part of the gatherings inside and outside the house in Foster Street have not only made neighbours’ lives a misery through their excessive noise and anti-social behaviour, by not adhering to the lockdown regulations they have increased the chances of the coronavirus spreading, putting more lives at risk and potentially unnecessary strain on emergency medical care.
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"They have also tied up a significant amount of police resources at a time when, like all other emergency services and key workers, our officers and staff are putting their own lives and the lives of their families at risk on a daily basis whilst working in really challenging circumstances."
Police Constable Ian Prashar, of the Halton Problem Solving Team, added: "The behaviour of people inside and outside the address in Foster Street caused those living in nearby properties significant alarm, harassment and distress.
"I am delighted that the closure order has been secured and I want to thank the members of the public who played a key role in this.
"The information they supplied was crucial in us gathering the evidence needed to secure the order. We want people to be able to live in their homes without having to suffer from the effects of unacceptable issues at neighbouring properties.
"The closure order is another example of our commitment to targeting those who undermine our communities and have a significant detrimental impact on the quality of life of local residents through unacceptable behaviour.
"I hope that this case encourages others to report and give statements regarding such behaviour at properties they live near. As this case shows, we will do something about it."
Anyone who is concerned about anti-social behaviour or group gatherings in their community is urged to call Cheshire Constabulary on 101 or provide the details via the website.
Alternatively, residents can report information anonymously to Crimestoppers on 0800 555 111.
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